Seventeen trials in total: hypertension in older patients, 7 trials (13,154 patients); mild-to-moderate hypertension in young patients, 5 trials (22,967 patients); non-moderate hypertension, 3 trials (334 patients); poststroke hypertension, 2 trials (551 patients).
1. Mortality.
Hypertension in older people: OR 0.90 (95% confidence interval, CI: 0.81, 1.00); ARR -3 (95% CI: -6, 0); NTT 382; p<0.05.
Mild-to-moderate hypertension in younger people: OR 0.98 (95% CI: 0.82, 1.11, p=0.79).
Non-moderate hypertension: OR 0.62 (95% CI: 0.22, 1.78, p=0.37).
Poststroke hypertension: OR 0.77 (95% CI 0.48, 1.24, p=0.28).
2. Cardiovascular death.
Hypertension in older people: OR 0.77 (95% CI: 0.67, 0.89); ARR -4 (95% CI: -8, -1); NTT 225; p<0.001.
Mild-to-moderate hypertension in younger people: OR 0.96 (95% CI: 0.78, 1.21, p=0.76).
Non-moderate hypertension: OR 0.66 (95% CI: 0.20, 2.15, p=0.49).
Poststroke hypertension: OR 0.64 (95% CI: 0.37, 1.11, p=0.11).
3. Stroke.
Hypertension in older people: OR 0.66 (95% CI: 0.56, 0.77); ARR -5 (95% CI: -8, -2); NTT 197; p<0.001.
Mild-to-moderate hypertension in younger people: OR 0.51 (95% CI: 0.39, 0.69); NTT 833; p<0.001.
Non-moderate hypertension: OR 0.62 (95% CI: 0.17, 2.24, p=0.46).
Poststroke hypertension: OR 0.65 (95% CI: 0.43, 0.99); NTT 31; p<0.05.
4. Major coronary event
Hypertension in older people: OR 0.79 (95% CI: 0.68, 0.92); ARR -3 (95% CI: -4, -1); NTT 362; p<0.01.
Mild-to-moderate hypertension in younger people: OR 0.96 (95% CI: 0.81, 1.14, p=0.66).
Non-moderate hypertension: OR 0.63 (95% CI: 0.17, 2.27, p=0.48).
Poststroke hypertension: OR 0.94 (95% CI: 0.30, 2.95, p=0.92).
5. Congestive heart failure
Hypertension in older people: OR 0.54 (95% CI: 0.43, 0.68); ARR -5 (95% CI: -7, -3); NTT 190; p<0.001.
Mild-to-moderate hypertension in younger people: OR 0.22 (95% CI: 0.03, 1.56, p=0.13).
Non-moderate hypertension: OR 0.14 (95% CI: 0.05, 0.41); NTT 24; p<0.001.
Poststroke hypertension: OR 0.31 (95% CI: 0.10, 2.95); NTT 88; p<0.05.