Thirteen studies (total n=558) provided data on both lipid and blood-pressure effects of indapamine.
Thirty-one studies (total n=989) provided data on thiazides, 430 patients in low-dose studies and 559 patients in high-dose studies.
The total cholesterol increased from baseline by 1.4% on indapamide, 3.8% on low-dose thiazides and 6.3% on high-dose thiazides. The change from baseline was significantly greater for high-dose thiazides than for indapamide (p<0.01). Changes in high-density lipoprotein cholesterol did not differ among groups. The change in triglycerides differed among regimens, -0.5%, 10.8%, and 19.5% for indapamide, low-dose thiazides, and high-dose thiazides, respectively (p<0.01). Systolic blood-pressure (SBP) decreased by 13 and 18 mmHg on low-dose and high-dose thiazides, respectively (p<0.05 between doses). Indapamide lowered SBP by 16 mmHg, not different from either thiazide dose. Diastolic blood-pressure did not differ among groups.