Thirty-three studies (95 men, 584 premenopausal women and 682 postmenopausal women) were included: 27 studies were considered, at least in part, to administer suppressive therapy (95 men, 385 premenopausal women and 420 postmenopausal women); 13 studies were considered, at least in part, to deal with the effect of replacement therapy (199 premenopausal and 262 postmenopausal women).
Standardised effect size of suppressive therapy for men: 0.082 (p=0.62) on lumbar spine.
Standardised effect size of suppressive therapy for premenopausal women: 0.231 (p=0.007) on lumbar spine, 0.02 (p=0.87) on femoral neck, 0.052 (p=0.74) on greater trochanter, 0.134 (p=0.39) on Ward's triangle, 0.029 (p=0.84) on distal radius, and -0.178 (p=0.18) on proximal radius.
Standardised effect size of suppressive therapy for postmenopausal women: -0.348 (p<0.0001) on lumbar spine, -0.276 on femoral neck, -0.484 (p=0.0003) on greater trochanter, -0.386 (p=0.012) on Ward's triangle, -0.328 (p=0.018) on distal radius, and -0.448 (p=0.002) on proximal radius.
Standardised effect size of replacement therapy for premenopausal women: -0.295 (p=0.018) for lumbar spine, -0.545 (p<0.0001) on femoral neck, -0.941 on greater trochanter, -0.481 (p=0.009) on Ward's triangle, -0.327 (p=0.083) on distal radius, and -0.498 (p=0.004) on proximal radius.
Standardised effect size of replacement therapy for postmenopausal women: -0.125 (p=0.29) for lumbar spine, -0.106 (p=0.39) on femoral neck, -0.105 on greater trochanter, -0.209 (p=0.11) on Ward's triangle, -0.407 on distal radius, and -0.641 on proximal radius.