Study designs of evaluations included in the review
Randomised controlled trials (RCTs) were included.
Specific interventions included in the review
Hypertonic 7.5% saline (HS) alone or with dextran-70 (HSD), usually at a 6% concentration. In all cases, administration of 250 mL of HSD or HS was compared with a control group administration of 250 mL of isotonic crystalloid for the treatment of hypotension either in the field or at admission to the emergency department.
Participants included in the review
Adult patients (16 years or older) with a systolic blood-pressure of less than 100 mmHg associated with traumatic injury.
Outcomes assessed in the review
The outcome was survival until discharge or 30-day survival.
How were decisions on the relevance of primary studies made?
The authors do not state how the papers were selected for the review, or how many of the authors performed the selection.