Twenty RCTs (4,610 cycles) were included in the review.
Pooled data from all studies showed no significant difference between rFSH and urinary-derived FSH gonadotrophins, in general, in the clinical pregnancy rate per cycle started (OR 1.07, 95% CI: 0.94, 1.22). Neither was the difference statistically significant between rFSH and human menopausal gonadotrophin, purified FSH, or highly purified FSH.
The studies were statistically homogeneous. The funnel plot indicated that publication bias was unlikely to have influenced the findings.