A total of 20 studies (n=827 patients with 2,717 nodules) were included in the review.
CAD sensitivity ranged from 38% to 100% across studies. Overall sensitivity of CAD was reported as 79% (95% CI: 72% to 82%). Overall sensitivity of CAD when used by a radiologist was reported as 92% (95% CI: 85% to 99%).
The average absolute number of false-positives nodules per patient was 18.1 (95% CI: 4.1 to 32.1).
Sensitivity of 80% was reported for CAD studies using thin section protocols (10 studies, n=409). When studies using low-dose protocols were excluded, sensitivity was 90% (six studies, n=93).
Sensitivity of 74% was reported for CAD studies using thick section protocols (eight studies, n=421).
Sensitivity of 73% was reported for CAD studies using low-dose protocols (eight studies, n=409).
Sensitivity of 81% was reported for CAD studies using normal dose protocols (12 studies, n=438).