Randomised controlled trials (RCTs) of participants of any age with diabetic leg or foot ulceration with interventions performed in any setting were eligible for inclusion. Studies had to compare autografts (pinch, split or full-thickness skin grafts, cultured keratinocytes or fibroblasts), allografts (cultured keratinocytes or fibroblasts), xerografts or bioengineered skin with any other intervention. The primary outcome of interest was complete healing rate at end of trial.
The included studies compared dermal allografts and bioengineered skin to standard care and combined epidermal and dermal autograft (cultured fibroblasts and keratinocytes) to control (unspecified). None of the studies provided a description of study setting.
Two reviewers independently performed study selection. Disagreements were resolved by discussion.