Nineteen studies (n=522) were included in the meta-analysis. Ten studies (n=125, but n=257 was reported in the paper) compared treatments with an active control group.
Anxiety symptoms:
Within-group analyses demonstrated statistically significant large effects for: CBT without relaxation training (SMD 1.18, 95% CI 0.78 to 1.59); CBT with relaxation training (SMD 0.86, 95% CI 0.63 to 1.08); and relaxation training alone (SMD 0.91, 95% CI 0.68 to 1.24). There was a medium effect for active control conditions (SMD 0.50, 95% CI 0.22 to 0.78) compared with a non-significant small effect for wait list or no treatment. Pairwise comparisons showed a statistically significant difference only between CBT without relaxation training and the active control group. There was statistically significant heterogeneity between all studies (p=0.001), but not among studies within each treatment group.
Comparisons of treatments with an active control showed a large and statistically significant effect for relaxation training alone (SMD 0.90, 95% CI 0.44 to 1.44) and non-significant small effects for CBT with or without relaxation training. There was statistically significant heterogeneity between the studies (p<0.0001) and within the relaxation training treatment groups (p<0.0001). Pairwise comparisons were not significant.
Depressive symptoms:
Within-group analyses demonstrated statistically significant large effects for: CBT without relaxation training (SMD 0.78, 95% CI 0.38 to 1.17); CBT with relaxation training (SMD 0.77, 95% CI 0.55 to 1.00); and relaxation training alone (SMD 0.77, 95% CI 0.26 to 1.27). There was a medium effect for active control conditions (SMD 0.53, 95% CI 0.24 to 0.82) compared with a non-significant small effect for wait list or no treatment. Pairwise comparisons showed a significant difference only between CBT with relaxation training and the wait list or no treatment group. There was no evidence of heterogeneity.
Comparisons with an active control showed small effect sizes, with no statistically significant differences between any of the treatments. There was statistically significant heterogeneity between studies (p=0.01), and amongst studies of relaxation training (p=0.001).