Twenty-one studies were included (n=over 5,000 participants, range four to 2,033 participants). Eleven studies involved actor modification. Two studies involved decision support modification. Eight studies involved treatment modifications. Nine studies involved systems modifications. Categories were not mutually exclusive.
Actor modification: Only two out of 11 studies were randomised; only two used an educational intervention alone and these did not show improvements in outcomes related to the intervention.
Decision support modification: Patients within both studies were severely cognitively impaired and interventions were intended to reduce discomfort. One study reported a significant increase in scheduled analgesics and non-pharmacological comfort interventions and a decrease in the modified Discomfort Scale-Dementia of the Alzheimer's Type (DS-DAT) scores. The other report had high attrition and reported a higher persistence to treat and decrease in DS-DAT in the intervention arm.
Treatment modification: Five studies used non-pharmacological treatment modifications; two reported less pro re nata (PRN) medication use and improved pain index measures, but differences were not assessed statistically. The authors stated that overall treatment modification studies were more rigorously designed than other interventions, and results were not encouraging.
Systems modification: Five of the nine studies examined process and resident endpoints; four reported decreased pain.
Further details of individual studies were provided in the review.