This was a comprehensive modelling study showing the cost-effectiveness of a therapeutic agent in the prevention of fracture from osteoporosis. Multiple results using different analytical methods were presented in the study.
(a) The therapeutic treatment was never described in the study.
(b) Full justification of assumptions about the effectiveness of treatment used in the model was needed in order to clarify the relative importance of the cost-effectiveness result of the study.
(c) It was not clear whether an incremental analysis was performed.