(This commentary was not written by CRD, but by the authors of the DH Register.)
1) There is no evidence that screening affects survival. 2) The model extrapolates from a small case series of uncertain generalisability. 3) Costs of treatment are not included. 4) This is an illustrative study. 5) The summary C/LY value is wishful. 6) The parameters investigated by sensitivity analysis and the range of values were not adequately justified.