Wound complications were as follows:
Oral Group = 0, Intravenous Group = 2 (20%).
No implant infections occurred in either group.
Adverse effects were as follows:
Oral Group = 1 (10%), Intravenous Group = 0.
Mean serum/tissue levels (micrograms/ml) were as follows:
Ofloxacin = 2.75 (range: 0.4-4.2)/0.55 (range: 0.4-0.9) - serum to tissue ratio = 5.0,
Gentamicin = 2.6 (range: 1.7-3.8)/0.45 (range: 0-0.5) - serum to tissue ratio = 5.0,
Cefazolin = 24.5 (range: 21.5-76)/4.9 (range: 2.3-6.8) - serum to tissue ratio = 5.77.
The difference in mean serum-to-tissue ratios between ofloxacin and the combination of cefazolin and gentamicin had a p value < 0.03.