Base-case primary outcome probabilities were:
MTF (mild thyroid failure) prevalence = 0.056 (women aged 35 years), 0.027 (men aged 35 years);
reversible MTF symptoms = 0.280 (men and women);
positive antithyroid antibodies in MTF = 0.670 (women), 0.400 (men);
MTF serum total cholesterol => 6.2 mmol/L (240mg/dL) = 0.250 (men and women);
develop MTF = 0.0028 (women), 0.0014 (men);
develop overt hypothyroidism if positive antibody = 0.054 (women), 0.0265 (men);
overt thyroid disease presents as complicated myxedema = 0.003;
seek medical attention because of MTF symptoms = 0.500;
death from complicated myxedema = 0.600;
reduction in cholesterol with levothyroxine sodium = 17%;
reduction in cholesterol with lipid-lowering therapy = 12%.
utilities for health states including euthyroid:
MTF and no symptoms, 1.0;
MTF with symptoms, 0.9;
overt hypothyroidism, 0.74;
complicated myxedema, 0.4;
myocardial infarction, 0.87;
uncomplicated angina pectoris, 0.75;
intermittent claudication, 0.85;
and cerebrovascular accident, 0.4.