The effectiveness results were as follows:
Of the initial sample of 518 patients, 403 (78%) had their symptoms controlled due to the therapy.
Of these 403 patients, 243 (60%) were successfully treated and were discharged from the hospital back to the community.
62 (15%) were successfully treated and were waiting to be discharged, and 99 (25%) had improved substantially but were still hospitalised.
A total of 115 (22%) patients discontinued the therapy for various reasons.
There was a 0.9% incidence of agranulocytosis in the total study population.
The effectiveness results of the subgroup were as follows:
In the subgroup of 189 patients the average admission BPRS score was 64, and the average discharge score was 37.
From admission values, BPRS scores were reduced after 2 months of therapy (22%), 3 months (28%), 6 months (33%), and 12 months (42%).
After 12 months of clozapine therapy, only 55 (29%) of the original 189 hospitalised patients remained in hospital.
The number of injuries resulting from aggressive behaviour declined in 1 hospital location between 1990 and 1994 as the number of patients on clozapine therapy increased.