The results of the review were as follows:
The prevalence of GERD in patients with non-cardiac chest pain was 60% (Sensitivity analysis (SA) was undertaken for values between 20-80%).
30% of patients with a negative omeprazole test were expected to have an esophageal motility disorder as the cause of their symptoms (SA: 10-50%).
The authors assumed 10% of patients had a functional cause for their chest pain symptoms (SA: 2-25%).
The sensitivity of the omeprazole test was 78% (SA: 20-100%) and the specificity was 86% (SA: 20-100%).
The sensitivity of upper gastrointestinal endoscopy was 40% (SA: 10-100%) and the and specificity was 95% (SA: 10-100%).
The sensitivity and specificity of 24-hour ambulatory pH monitoring was 85% (SA: 20-100%).
The sensitivity and specificity of the esophageal manometry was 60% (SA: 30-90%).
45% to 65% of patients with a primary motility disorder would respond to diltiazem 60 mg three times daily and 50% to 75% of patients with functional chest pain would respond to therapy with low-dose tricyclic anti-depressants.