The resistance of 246 H. pylori against metronidazole was categorized into three levels: sensitive (below MIC 8 micro g/ml), medium (between 8 micro g/ml and 32 micro g/ml), and resistant (above 32micro g/ml). For metronidazole resistance testing the Epsilometer test revealed 205 cases as sensitive, 10 cases as medium and 31 cases as resistant while the disk diffusion test revealed 208 cases as sensitive and 38 cases as resistant. The results of the two tests were correlated at a value of 92.7%. The resistance of 246 H. pylori against clarithromycin was categorized into three levels: sensitive (below MIC 2 micro g/ml), medium (between 2 micro g/ml and 8 microg/ml), resistant (above 8 micro g/ml). For clarithromycin resistance testing the Epsilometer test revealed 213 cases as sensitive, 2 cases as medium and 31 cases as resistant while the disk diffusion test revealed 212 cases as sensitive and 34 cases as resistant. The results of the two tests were correlated at a value of 98%.