The base-case evaluated the cost of treating a patient with 7 to 20 facial AKs twice in one calendar year, based on the lesional response rate.
On the basis of the lesional response of cured facial AKs, the base-case costs were $501.62 with the 5% cream, $418.56 with the 1% cream, and $330.52 with the 0.5% cream. On the basis of the patient cure rates, the base-case costs were $704.68 with the 5% cream, $587.99 with the 1% cream, and $464.31 with the 0.5% cream.
From the sensitivity analysis, the costs based on the lesional response rate of cured facial AK were:
for one treatment per year, $248.50 (1 - 6 lesions) and $364.82 (more than 6 lesions) with the 5% cream, $218.29 (1 - 6 lesions) and $304.41 (more than 6 lesions) with the 1% cream, and $240.38 (1 - 20 lesions) with the 0.5% cream;
for two treatments per year, $341.68 (1 - 6 lesions) and $501.62 (more than 6 lesions) with the 5% cream, $300.15 (1 - 6 lesions) and $418.56 (more than 6 lesions) with the 1% cream, and $330.52 (1 - 20 lesions) with the 0.5% cream.
From the sensitivity analysis, the costs based on patients cured of facial AKs were:
for one treatment per year, $349.09 (1 - 6 lesions) and $512.50 (more than 6 lesions) with the 5% cream, $306.66 (1 - 6 lesions) and $427.63 (more than 6 lesions) with the 1% cream, and $337.68 (1 - 20 lesions) with the 0.5% cream;
for two treatments per year, $480.00 (1 - 6 lesions) and $704.68 more than 6 lesions) with the 5% cream, $421.65 (1 - 6 lesions) and $587.99 (more than 6 lesions) with the 1% cream, and $464.31 (1 - 20 lesions) with the 0.5% cream.