The dose of fentanyl rescue was 112 (+/- 64) microg in the placebo group, 114 (+/- 90) microg in the acetaminophen group, 78 (+/- 80) microg in the celecoxib group, (p<0.05 versus placebo and acetaminophen), and 45 (+/- 60) microg in the rofecoxib group, (p<0.05 versus all the other drugs).
The median peak pain score during PACU stay was 5 (interquartile range, IQR: 0 - 9.5) in the placebo group, 5 (IQR: 1 - 9) in the acetaminophen group, 4 (IQR: 1 - 7) in the celecoxib group, (p<0.05 versus placebo), and 2.5 (IQR: 0 - 6) in the rofecoxib group, (p<0.05 versus all other groups).
The median peak pain score at home was 5 (IQR: 1 - 9) in the placebo group, 2 (IQR: 0 - 7) in the acetaminophen group, (p<0.05 versus placebo), 0 (IQR: 0 - 4) in the celecoxib group, (p<0.05 versus placebo), and 0 (IQR: 0 - 2) in the rofecoxib group, (p<0.05 versus placebo and acetaminophen).
The proportion of patients requiring pre-discharge analgesic rescue medication was 88% in the placebo group, 85% in the acetaminophen group. 70% in the celecoxib group, (p<0.05 versus placebo), and 47% in the rofecoxib group, (p<0.05 versus all other groups).
The peak nausea score, rate of patients vomiting, and proportion of patients receiving antiemetics in the PACU were not significantly different across the groups.
The maximum verbal pain score after discharge was 5 (IQR: 1 - 9) in the placebo group, 2 (IQR: 0 - 7) in the acetaminophen group, (p<0.05 versus placebo), 0 (IQR: 0 - 4) in the celecoxib group, (p<0.05 versus placebo and acetaminophen), and 0 (IQR: 0 - 2) in the rofecoxib group, (p<0.05 versus placebo and acetaminophen).
The number of doses of oral analgesic medication after discharge was 3 (+/- 2) in the placebo group, 3 (+/- 2) in the acetaminophen group, 2 (+/- 2) in the celecoxib group, (p<0.05 versus placebo and acetaminophen), and 1 (+/- 1) in the rofecoxib group, (p<0.05 versus all other groups).
The maximum verbal nausea score post-discharge was 1.5 (+/- 2.1) in the placebo group, 1.2 (+/- 2.4) in the acetaminophen group, 0.7 (+/- 2) in the celecoxib group, and 0.1 (+/- 0.6) in the rofecoxib group, (p<0.05 versus placebo and acetaminophen).
The rate of patients completely satisfied with pain management was 15% in the placebo group, 34% in the acetaminophen group, (p<0.05 versus placebo), 48% in the celecoxib group, (p<0.05 versus placebo and acetaminophen), and 70% in the rofecoxib group, (p<0.05 versus all other groups).
The patient satisfaction scores with anaesthetic management were 95 (+/- 9) in the placebo group, 98 (+/- 5) in the acetaminophen group, (p<0.05 versus placebo), 96 (+/- 7) in the celecoxib group, and 99 (+/- 3) in the rofecoxib group, (p<0.05 versus placebo and celecoxib).
The patient satisfaction scores with postoperative pain control were 83 (+/- 15) in the placebo group, 88 (+/- 15) in the acetaminophen group, (p<0.05 versus placebo), 93 (+/- 10) in the celecoxib group, (p<0.05 versus placebo and acetaminophen), and 97 (+/- 5) in the rofecoxib group, (p<0.05 versus all other groups).
The quality of recovery score was 84 (+/- 15) in the placebo group, 86 (+/- 16) in the acetaminophen group, 89 (+/- 14) in the celecoxib group, 95 (+/- 7) in the rofecoxib group (p<0.05 versus all other groups).
The NNT for complete patient satisfaction with pain control compared with placebo was 5.5 (95% confidence interval, CI: 3.1 - 73.8) with acetaminophen, 3.2 (95% CI: 2.2 - 7.3) with celecoxib, and 1.9 (95% CI: 1.5 - 3.0) with rofecoxib.
The NNT for complete patient satisfaction with pain control compared with acetaminophen was 7.5 (95% CI: 3.2 - 17.8) with celecoxib and 3.0 (95% CI: 2.0 - 7.2) with rofecoxib.
The NNT for complete patient satisfaction with pain control with rofecoxib compared with celecoxib was 5.0 (95% CI: 2.6 - 166).