1. Combination therapy is better than monotherapy; there are good arguments for starting treatment with triple therapy.
2. There appears to be no benefit in early treatment (i.e. when CD4 counts are still above 500cells/mm3).
3. It is not possible to give a simple best choice of combination treatment. It has to be decided for individual patients, taking into account factors such as previous treatment.
4. The best prophylactic treatment for pneumocystis carinii is co-trimoxazole.
5. Maternal transmission is reduced by AZT. Trials of combination therapy are needed.
6. We need better evidence on how to deal with prophylaxis after needlestick injuries, but in the meantime they should be treated with urgency with combination therapy given as soon as possible.
7. Costs will rise due to increased drug costs and better survival.