The prevailing evidence does not support the use of either dedicated or modified camera-based PET as a diagnostic test for the applications in this review. The TA Program identified several methodologically rigorous studies of other diagnostic imaging modalities that could serve as models for designing higher quality PET research
Systematic reviews from other technology assessment agencies, which used methods similar to VHA's derived similar conclusions. As in VHA, patients with cancer constitute a considerable burden to the health systems represented by these agencies, and there is growing support for assessing either PET modality in the work up of these patients.
Several cooperative trials, including a VHA cooperative study of PET in solitary pulmonary nodules, are ongoing or planned. Clinicians should await the results of these efforts before incorporating PET into routine diagnostic strategies.