Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Alberta Heritage Foundation for Medical Research. Etanercept (Enbrel(R)) Edmonton: Alberta Heritage Foundation for Medical Research (AHFMR). Emerging Technology Report. 2000 Authors' objectives This report aims to summarise the available evidence on the use of etanercept (Enbrel(R)) in the treatment of rheumatoid arthritis. Authors' conclusions Enbrel(R) has been approved by the FDA for treatment of juvenile rheumatoid arthritis and severe to moderate rheumatoid arthritis. It is for use in patients who have an inadequate response to one or more disease-modifying anti-rheumatic drugs.
Enbrel(R) inhibits the binding of tumor necrosis factor (TNF) to its receptor. TNF is a protein secreted by certain immunoregulatory cells. Normally this protein helps fight infection; however in an autoimmune disease it contributes to the inflammation which destroys joints.
In a study, 69 patients aged 4 to 17 years were treated for three months with Enbrel(R). These patients had discontinued treatment with methotrexate due to intolerance or poor response. Fifty-one patients (74%) showed improvement. This group of responders was then divided into two groups to continue receiving Enbrel(R) or placebo. Those who continued on the drug remained stable, while those on placebo deteriorated. When restarted on Enbrel(R), the placebo group improved again.
Indexing Status Subject indexing assigned by CRD MeSH Arthritis, Juvenile Rheumatoid /drug therapy; Arthritis, Rheumatoid /drug therapy Language Published English Country of organisation Canada English summary An English language summary is available. Address for correspondence 1200, 10405 Jasper Avenue, Edmonton, Alberta, Canada, T5J 3N4. Tel: +1 780 448 4881; Fax: +1 780 448 0018 Email: djuzwishin@ihe.ca AccessionNumber 32000000855 Date bibliographic record published 07/08/2000 Date abstract record published 07/08/2000 |