This meta-analysis demonstrates that PPIs are effective in functional dyspepsia as compared with placebo. Based on other meta-analyses, prokinetic agents such as cisapride and H2-antagonists have lower NNTs than PPIs and thus might appear more efficacious. Unfortunately, there are no direct comparison trials between the three agents and therefore there is no conclusive evidence that one agent is the best. Only one trial has demonstrated no difference between PPIs and H2-antagonists. Further RCTs comparing PPIs, other prokinetic agents (such as domperidone), and H2-antagonists, in H.pylori positive and negative patients with functional dyspepsia, are needed.