- Inhaled tiotropium provides a sustained bronchodilator effect over a 24-hour period in patients with chronic obstructive pulmonary disease (COPD).
- There is some evidence that tiotropium 18g once daily is more efficacious than ipratropium bromide 40 g four times daily, for patients with COPD, as measured by improvements in lung function, dyspnea disease-specific quality of life and reductions in hospitalization due to COPD.
- Dry mouth is a more frequent problem with tiotropium than with ipratropium bromide.