- One systematic review published in 1997 was retrieved. We found no studies on this topic published since 1997.
- The review examined the effectiveness of intrathecal baclofen on general severe spasticity. High-level evidence for hereditary spastic paraplegia is lacking.
- Data from 27 studies representing the experience of 490 patients is examined.
- Primary endpoints include changes in Ashworth and Penn scores, duration of follow-up, and dosage at last follow-up - Mean Ashworth scores decreased from 3.9 to 1.6 (p<0.001) - Mean Penn scores decreased from 3.5 to 0.7 (p<0.001) - Cumulative success of 78.1% was reported - Over 16 months, dosage increased by an average of 250% from baseline.