- Findings from a systematic review and a case series have shown that Metformin related lactic acidosis occurs mainly in patients with abnormal renal function. For this reason the authors agree that Metformin should be discontinued for 48 hours after the use of contrast media in patients with abnormal renal function, and that renal function should be reassessed before Metformin is reinstituted
- There appears to be a lack of evidence behind the requirement to withhold Metformin after the use of contrast media in patients with normal renal function