Citation Hummel S, Paisley S, Morgan A, Currie E, Brewer N. Clinical and cost-effectiveness of new and emerging technologies for early localised prostate cancer: a systematic review. Health Technology Assessment 2003; 7(33): 1-170 Authors' objectives <p>This report is a review of the clinical and cost-effectiveness of new and emerging technologies for early, localised prostate cancer. A systematic review was undertaken to identify new and emerging technologies and to evaluate clinical and cost-effectiveness through assessment of the best available evidence. The review aimed to assess clinical effectiveness in terms of survival, disease-free survival, quality of life (QoL), including complications and adverse events) and acceptability.</p>
Authors' conclusions Given the lack of high-quality clinical evidence with long-term follow-up and the uncertainty surrounding the assumptions in the economic analysis, the following areas are recommended for further research:
- RCTs with sufficient follow-up to measure benefits in terms of overall survival to include QoL measurement to establish trade-offs between potential adverse events and benefits of treatment. - The identification of prognostic risk factors among men diagnosed with early prostate cancer. - QoL studies to compare the utility of health states among patients on active monitoring, patients receiving treatment and the comparable healthy population. - The relationship between surrogate end-points and survival. - The adoption of standard definitions for adverse events.
INAHTA brief and checklist Indexing Status Subject indexing assigned by CRD MeSH Costs and Cost Analysis; Prostatic Neoplasms /therapy Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence NETSCC, Health Technology Assessment, Alpha House, University of Southampton Science Park, Southampton, SO16 7NS UK Tel: +44 23 8059 5586 Email: hta@hta.ac.uk AccessionNumber 32003001162 Date bibliographic record published 12/12/2003 Date abstract record published 12/12/2003 |