For the combinations and conditions studied, the pooled analysis of smaller studies does not show evidence of an effect of vitamin E alone or in combination with other agents on all-cause mortality, cardiovascular mortality, fatal or nonfatal MI, or blood lipid levels. Results from a number of large clinical trials not included in the pooled analysis were substantially in agreement with this conclusion. Large studies of vitamin C in combination with other antioxidants for the prevention of cardiovascular disease reported no favorable outcomes. There is no convincing evidence either supporting or refuting the value of coenzyme Q10 in cardiovascular disease.