A systematic review of the literature was undertaken to address the following questions: - What are the current indications for, and outcomes from, primary total knee replacement?
- How do specific characteristics of the patient, material and design of the prosthesis, and surgical factors, affect the short-term and long-term outcomes of primary total knee replacement?
- Are there important perioperative interventions that influence outcomes?
- What are the indications, approaches, and outcomes for revision total knee replacement?
- What factors explain disparities in the utilization of total knee replacement in different populations?
- What are the directions for future research?