Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Moga C, Harstall C, Tang Z. Celecoxib for the treatment of pain in osteoarthritis and rheumatoid arthritis. Edmonton: Alberta Heritage Foundation for Medical Research (AHFMR). AHFMR - Information Paper #24. 2005 Authors' objectives The objective of this review was to present the current evidence on the efficacy/effectiveness and safety of celecoxib (Celebrex (R)) for the treatment of pain in patients with osteoarthritis (OA) and rheumatoid arthritis (RA).
Authors' conclusions Overall, short-term use of celecoxib was equivalent to non-selective NSAIDs (naproxen and diclofenac) and other COX-2 inhibitors (nimesulide and rofecoxib) and was superior to acetaminophen in reducing pain and improving function for patients with RA and OA. Short-term use of celecoxib was associated with a reduction in rates of gastroduodenal erosions or ulcers compared with those for non-selective NSAIDs (naproxen, ibuprofen, and diclofenac) in patients with RA and OA. Many questions remain to be addressed about the long-term safety of celecoxib compared with non-selective NSAIDs and about the combination treatment of NSAIDs and other types of drugs. Health Canada recommended usage restrictions for Celebrex beginning in April 2005. Celebrex should not be used in patients who have had a heart attack or stroke, serious chest pain related to hearth disease, or congestive heart failure. Celebrex may increase the risk of cardiovascular events in patients with high blood pressure, high cholesterol, diabetes, and smoking. Also, Celebrex should be prescribed and used at the lowest possible dose and for the shortest, necessary period of time.
INAHTA brief and checklist Indexing Status Subject indexing assigned by CRD MeSH Anti-Inflammatory Agents, Non-Steroidal /therapeutic use; Arthritis, Rheumatoid /drug therapy; Pyrazoles /therapeutic use; Sulfonamides /therapeutic use Language Published English Country of organisation Canada English summary An English language summary is available. Address for correspondence 10405-103 Avenue, 1200, Edmonton Alberta, T5J 3N4 Canada, Tel: +1 780 423 5727, Fax: +1 780 429 3509 Email: djuzwishin@ihe.ca AccessionNumber 32005000436 Date bibliographic record published 20/08/2005 Date abstract record published 20/08/2005 |