To consider the role of SPECT for the assessment of patients with schizophrenia , it would be necessary to have the results of less specialized centers, multicentric studies, in defined populations of consecutive patients and standardized analytical methods. Functional imaging methods do not play an important role in the diagnosis and treatment of schizophrenia and are still considered investigational methods, contributing to the knowledge about the pathophysiological base of this disease. Nowadays, important health organizations in the U.S.A. do not consider SPECT as an indication for patients with schizophrenia.