Our review indicates a very limited evidence base with which to address all four of the research questions:
1.The few evaluations of cancer risk prediction models do not suggest useful individual predictive accuracy.
2.The experimental evidence base for primary and secondary cancer prevention is very limited.
3.There is insufficient evidence to assess the effect of FHx-based risk assessment on preventive behaviors.
4.There is insufficient evidence to assess whether FHx-based personalized risk assessment directly causes adverse outcomes.