Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mundy L, Hiller JE. Cytochrome P450 gene test to establish the correct warfarin dose in patients requiring oral anti-coagulant therapy. Adelaide: Adelaide Health Technology Assessment (AHTA). Horizon Scanning Prioritising Summary Volume 26. 2010 Authors' conclusions Polymerase chain reaction is an accurate means of identifying genetic mutations. All techniques discussed in this summary use PCR and other molecular techniques as the basis of their methodology. All commercial platforms and in-house assays assessed proved to be accurate for identifying the specific polymorphisms of the CYP2C9 and VKORC1 genes that are considered to be important in warfarin metabolism. Of the assays assessed, the single-nucleotide polymorphism SMart-amplification assay was the most rapid whilst still maintaining 100 per cent accuracy. However, large clinical trials are needed to determine the clinical utility of genotyping all patients prior to commencing warfarin therapy before pharmacogenomics enters routine clinical practice.It is likely that in five-years all patients currently on warfarin therapy will be placed on alternative pharmaceutical options. In addition, a two-week period of testing a patient's international normalised ratio is usually deemed sufficient to ascertain the correct warfarin dose. Therefore no further review on behalf of HealthPACT is required. Indexing Status Subject indexing assigned by CRD MeSH Anticoagulants; Cytochrome P-450 Enzyme System; Drug Dosage Calculationss; Warfarin Language Published English Country of organisation Australia English summary An English language summary is available. Address for correspondence Adelaide Health Technology Assessment, University of Adelaide, Discipline of Public Health, School of Population Health and Clinical Practice, Mail Drop DX650545, SA 5005 Adelaide Australia Email: tracy.merlin@adelaide.edu.au AccessionNumber 32010001663 Date abstract record published 15/12/2010 |