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Observational study to investigate vertically acquired passive immunity in babies of mothers vaccinated against H1N1v during pregnancy |
Puleston RL, Bugg G, Hoschler K, Konje J, Thornton J, Stephenson I, Myles P, Enstone J, Augustine G, Davis Y, Zambon M, Nicholson KG, Nguyen-Van-Tam JS |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Puleston RL, Bugg G, Hoschler K, Konje J, Thornton J, Stephenson I, Myles P, Enstone J, Augustine G, Davis Y, Zambon M, Nicholson KG, Nguyen-Van-Tam JS. Observational study to investigate vertically acquired passive immunity in babies of mothers vaccinated against H1N1v during pregnancy. Health Technology Assessment 2010; 14(55): 1-82 Authors' objectives The recent pandemic of 2009–10, although overall mild in impact, amply demonstrated that some individuals/groups are at increased risk of complications/death from influenza infection. Those at increased risk included pregnant women. Persuading patients to accept vaccination can be difficult, and in pregnancy there is rightly caution about providing any medical interventions unless the benefit outweighs the risk. This study was undertaken to determine if pregnant women vaccinated against A/H1N1v passed on humoral immunity to their unborn child and therefore would provide it with protection against acquiring influenza. Evidence that this was the case could be used by health policy-makers and clinicians to encourage women to accept protective vaccine in future pandemic influenza events, as well as seasonal influenza. Authors' conclusions This study provides evidence that maternal vaccination against monovalent A/H1N1v can provide humoral immunity to the unborn child, which may protect the baby against acquisition of the infection early in infancy when treatment options for infection are limited (because antiviral medications and immunisation are not licensed, have theoretical unwanted effects or may not be effective in this age group). The results will provide support to policy-makers and clinicians in advocating immunisation for pregnant women in future influenza epidemic and pandemic events, and will help pregnant women to make informed choices about vaccination under such circumstances. INAHTA brief and checklist Indexing Status Subject indexing assigned by NLM MeSH Adult; Confidence Intervals; Female; Great Britain /epidemiology; Health Policys; Immunity, Maternally-Acquired /immunology; Immunization Programs /statistics & Incidence; Infant Welfare; Infant, Newborn; Infectious Disease Transmission, Vertical /prevention & Influenza A Virus, H1N1 Subtype /immunology /isolation & Influenza Vaccines /immunology; Influenza, Human /epidemiology /prevention & Kaplan-Meier Estimate; Maternal Welfare; Mortality; Multivariate Analysis; Odds Ratio; Pandemics /prevention & Poisson Distribution; Pregnancy; Prevalence; Proportional Hazards Models; Prospective Studies; Risk Assessment; Surveys and Questionnaires; control /statistics & control /statistics & control /transmission; numerical data; numerical data; numerical data; purification Language Published English Country of organisation England Address for correspondence NETSCC, Health Technology Assessment, Alpha House, University of Southampton Science Park, Southampton, SO16 7NS UK Tel: +44 23 8059 5586 Email: hta@hta.ac.uk AccessionNumber 32011000118 Date abstract record published 02/02/2011 |
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