Eligible studies were experimental or observational studies of patients of high surgical risk with aortic stenosis or those deemed not suitable for surgical aortic valve replacement, where transcatheter aortic valve implantation was considered. Studies needed to report primary endpoints for feasibility and safety (including procedural success rate and 30-day mortality), secondary outcomes related to efficacy and durability (based on echocardiographic findings) and clinical outcomes at one, six and 12 months.
In the included studies, mean age ranged from 80 to 84 years. Mean/median logistic euroSCORE ranged from 11 to 37. Most studies used general not local anaesthetic. Definitions of high-risk patients varied across studies.
The number of reviewers who performed the study selection was not stated.