Some temporal augmentation treatments have proved to be useful in the treatment of lipodystrophy in HIV. In many cases the evidence of its usefulness is not enough and it comes from non-controlled trials including few patients.
Polylactic acid is the treatment studied in a higher number of studies that suggest its effectiveness with long-term follow-up. Although it does not present controlled studies, as is the case of most other implants, it requires several treatments, great volumes and its cost, in general, is high.
Most patients with lipodystrophy need more permanent treatments, at present PMMA and injectable silicones seem to be promising, but, controlled studies with longer follow-ups are still required to establish their long term efficacy and safety.
