1. For each form of active tuberculosis, to conduct systematic reviews to evaluate the accuracy of the following groups of tests in patients suspected of active TB: (a) nucleic acid amplification tests (b) amplification molecular probe tests (c) serodiagnostic and biochemical assays (d) phage-based tests.
2. To conduct a systematic review to evaluate how effective fully automated liquid culture systems are for isolating and identifying TB.
3. To conduct a systematic review to evaluate the use of interferon assays for detection of latent TB infection.
4. To examine the likely NHS and societal consequences of false-positive and-false negative tests.