Nicotine withdrawal symptoms are extremely prevalent among patients attempting to quit, and are often cited as the reason for relapse. Nicotine replacement therapy (NRT) is designed to facilitate smoking cessation by providing nicotine through alternative delivery methods, thereby reducing or eliminating withdrawal symptoms without the ill effects of tobacco smoke inhalation. NRT is available in the United States as nasal spray, inhaler, gum, lozenges/tablets, and transdermal patch; additional formulations, including a nicotine pouch and nicotine mouth spray, are available in some European countries. Absorption of nicotine from gum or lozenge occurs through the buccal mucous membrane.