The available evidence suggests that the clinical effectiveness of CBT delivered via tele-therapy in group and one-on-one sessions is comparable to face-to-face delivery. As well, overall participant satisfaction appeared to be comparable between the two delivery modes of group session CBT. However, due to issues with methodologies and factors that limit the generalizability of the results, the evidence should be interpreted with caution. No conclusions can be made about the clinical effectiveness of self-directed CBT, the cost-effectiveness of CBT delivered via tele-therapy or in a self-directed manner, or about which patients are best suited to the alternate delivery formats as no literature was identified. Before alternate delivery methods are widely adopted, more research is needed to determine their clinical effectiveness and to help identify which patients could most likely benefit from these approaches. In the absence of access to face-to-face care, however, tele-therapy with CBT may be an alternative used to treat patients with PTSD who would otherwise be without access to such an intervention.