There is a paucity of primary studies evaluating the efficacy and safety of benzodiazepines for the treatment of PTSD. In the available literature, benzodiazepines showed no clear benefit in the management of PTSD. The clinical practice guidelines generally agree that the data to support the use of benzodiazepines is limited in quality and quantity. Some of the guidelines suggested that benzodiazepines may be used for short term management of anxiety or sleep disturbances. Long term use of benzodiazepines to manage core symptoms of PTSD was not recommended by any of the guidelines. The limited available data on the use of benzodiazepines for PTSD may be a consideration for decision-making.