Overall, the evidence suggests that PET may be a useful tool in the diagnosis of CAD, particularly for patients with an intermediate likelihood of CAD, those who are obese, or those who are unable to exercise. The role of PET in the identification of patients with CAD who may benefit from revascularization is unclear. The lack of evidence from studies with high internal validity and the quality of the evidence that was used by the guideline development groups may be a consideration when deciding to use PET in the diagnosis or management of patients with CAD.