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Systematic review for effectiveness of hyaluronic acid in the treatment of severe degenerative joint disease
(DJD) of the knee |
Newberry SJ, Fitzgerald JD, Maglione MA, O'Hanlon CE, Booth M, Motala A, Timmer M, Shanman R, Shekelle PG |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Newberry SJ, Fitzgerald JD, Maglione MA, O'Hanlon CE, Booth M, Motala A, Timmer M, Shanman R, Shekelle PG. Systematic review for effectiveness of hyaluronic acid in the treatment of severe degenerative joint disease
(DJD) of the knee. Rockville: Agency for Healthcare Research and Quality (AHRQ). Technology Assessment Program. 2015 Authors' objectives The Coverage and Analysis Group at the Centers for Medicare and Medicaid Services (CMS) requested from The Technology Assessment Program (TAP) at the Agency for Healthcare Research and Quality (AHRQ), a review of the evidence that intraarticular injections of hyaluronic acid (HA) in individuals with degenerative joint
disease (osteoarthritis [HA]) of the knee improve function and quality of life (QoL) and that they delay or prevent the need for total knee replacement (TKR), specifically for individuals age 65 and over. Authors' conclusions Trials enrolling older participants show a small, statistically significant effect of HA on function and relatively few serious adverse events; however no studies limited participation to those 65 years or older. No conclusions can be drawn from the available literature on delay or avoidance of TKR through the use of HA. Studies that can compare large numbers of treated and untreated individuals, preferably with a randomized design, are needed to answer this question. Indexing Status Subject indexing assigned by CRD MeSH Humans; Hyaluronic Acid; Knee Joint; Osteoarthritis Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence AHRQ, Center for Outcomes and Evidence Technology Assessment Program, 540 Gaither Road, Rockville, MD 20850, USA Email: AHRQTAP@ahrq.hhs.gov AccessionNumber 32016000060 Date abstract record published 20/01/2016 |
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