Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Haute Autorité de Santé. Biologie des anomalies de l'hémostase : temps de thrombine et correction. [Biology of haemostasis disorders: thrombin time] Paris: Haute Autorité de Santé (HAS). 2011 Authors' objectives The National Salaried Workers' Health Insurance Fund (CNAMTS) asked HAS to assess the value of the different laboratory tests for haemostasis abnormalities with a view to updating the section in the Nomenclature of Procedures in Laboratory Medicine (NABM) containing the procedures in laboratory medicine for measuring abnormalities of haemostasis (subsection 5-02). One of those tests is the thrombin time (TT), an NABM procedure, which is a global test for the investigation of fibrin formation. The TT is the clotting time of citrated platelet-poor plasma (PPP) at 37°C in the presence of thrombin. Clot formation could be detected by chronometric, electromechanical or optical methods. A test of correction by adding control plasma can be carried out: the absence of any correction in TT indicates that unfractionated heparin is present in the sample. Historically, TT was used to make a preoperative assessment of haemostasis, investigate haemorrhagic syndrome or to detect the presence of unfractionated heparin in the sample.
Authors' conclusions According to the different documents analysed, TT is not recommended for use in the preoperative assessment of the risk of haemorrhage, the investigation of disseminated intravascular coagulation (DIC), the follow-up of heparin treatments, or for the diagnosis of other disorders such as von Willebrand's disease. It is still proposed for the diagnosis of rare congenital fibrinogen abnormalities. It should be noted that it is the determination of fibrinogen which is recommended in practice, and that this determination is already an NABM
procedure. In conclusion, TT is not advocated either for preoperative assessment of the risk of haemorrhage or for the investigation of haemorrhagic syndrome.
INAHTA brief and checklist Indexing Status Subject indexing assigned by CRD MeSH Blood Coagulation Disorders; Blood Coagulation Tests; Hemostasis; Humans; Thrombin Time Country of organisation France English summary An English language summary is available. Address for correspondence French National Authority for Health, 2, avenue du Stade de France, Saint-Denis La Plaine, FR-93218 Paris France
Tel: +33 1 55 937188 Email: international.affairs@has-sante.fr AccessionNumber 32016000267 Date abstract record published 11/02/2016 |