Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. Heartcel for heart failure in patients at risk of incomplete revascularisation following coronary artery bypass graft. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2016 Authors' objectives Heart failure is a common and disabling condition that affects the heart's ability to pump blood around the body. It is often caused by coronary artery disease, which happens when there is a build-up of fatty deposits in the blood vessels of the heart. These fatty deposits mean the heart muscle doesn't receive enough oxygen to work properly or they may completely block off a blood vessel leading to a heart attack (myocardial infarction), where a section of heart muscle dies completely forming a scar. Patients with heart failure may be treated with surgery in an operation called a coronary artery bypass graft, which improves blood flow to the heart muscle.
Heartcel is a stem cell therapy given as an injection into the heart muscle during a coronary artery bypass graft. Some studies have suggested that Heartcel may be helpful in improving the function of the heart following this surgery by regenerating the scar tissue associated with heart failure.
If Heartcel is licensed for use in the UK, it could be a new treatment option for patients undergoing coronary artery bypass graft surgery who are at high risk for it not managing to improve blood flow. Heartcel has the potential to reduce symptoms of heart failure and increase survival in this small group of patients. Indexing Status Subject indexing assigned by CRD MeSH Coronary Artery Bypass; Heart Failure; Humans Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence NIHR Horizon Scanning Research&Intelligence Centre, University of Birmingham, Institute of Applied Health Research, Public Health building, Edgbaston, Birmingham B15 2TT
Tel: 0121 414 9077 Email: nihrhsc@contacts.bham.ac.uk AccessionNumber 32016000634 Date abstract record published 19/04/2016 |