Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. Irinotecan-eluting beads (DC Bead, DC Bead M1 and DC Bead Lumi) for liver metastases secondary to colorectal cancer. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2016 Authors' conclusions Colorectal cancer is the fourth most common cancer in the UK, accounting for around 12% of all new cases of cancer. In metastatic colorectal cancer, the tumour has spread beyond the bowel to other parts of the body, most commonly the liver. Between 20% and 55% of people diagnosed with colorectal cancer have metastases when they are first diagnosed, and more than half of people who have undergone surgery for early stage colorectal cancer will develop advanced disease and distant metastases within 2 years of their initial diagnosis.
Irinotecan-eluting beads are designed to release irinotecan (a chemotherapy drug) at a slow rate directly to the site of the cancer, without affecting the surrounding healthy tissue. The irinotecan-eluting beads are delivered through the hepatic artery, a blood vessel that supplies blood to the liver.
Irinotecan-eluting beads are currently being studied to see how well they work in people with liver metastases secondary to colorectal cancer. Drug-eluting beads are already used to treat certain types of cancer in the UK. Indexing Status Subject indexing assigned by CRD MeSH Camptothecin; Colorectal Neoplasms; Humans; Liver Neoplasms; Topoisomerase I Inhibitors Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence NIHR Horizon Scanning Research&Intelligence Centre, University of Birmingham, Institute of Applied Health Research, Public Health building, Edgbaston, Birmingham B15 2TT
Tel: 0121 414 9077 Email: nihrhsc@contacts.bham.ac.uk AccessionNumber 32016000746 Date abstract record published 14/06/2016 |