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Laser interstitial thermal therapy for treating intracranial lesions and epilepsy: a health technology assessment and policy analysis |
Leggett LE, Coward S, Weaver C, Sevick LK, Zhang D, Mackean G, Lorenzetti D, Clement F
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Leggett LE, Coward S, Weaver C, Sevick LK, Zhang D, Mackean G, Lorenzetti D, Clement F
. Laser interstitial thermal therapy for treating intracranial lesions and epilepsy: a health technology assessment and policy analysis. Calgary: HTA Unit, University of Calgary 2016 Authors' conclusions Two studies on epilepsy and four on intracranial lesions (two of which assessed the same patient population) were included in this systematic review of LITT. Three studies were case
series, and two were non-randomized controlled studies. There was substantial heterogeneity among the included studies, in terms of LITT device used, type of LITT, comparator, patient population, and outcomes measured.
Among the two studies on epilepsy, one found that the LITT group experienced significantly less decline in famous face recognition and common names compared to SLAH. The other study found no statistically significant difference between seizure rates for those who had MRgLITT compared to anterior mesial temporal resection. Findings showed that length of stay was significantly shorter as was surgical time for those in the MRgLITT group, and the need for pain control was significantly less. Despite not finding a statistically significant improvement in seizure rates for those in the LITT group, this result suggests that LITT is equally effective at reducing seizures, while resulting in less pain, and shorter length of stay for patients.
Among the studies on intracranial lesions, one found that in the seven months after LITT, 71% of patients had tumor progression with a median progression free survival of 5.1 months. Another found mean time to progression was 16 months for low grade astrocytomas, 10 months for anaplastic gliomas and 4 months for glioblasomas. After LITT, this study found that mean survival times were 34 months for low grade astrocytomas, 30 months for anaplastic gliomas and 9 months for glioblasomas. The last study did not present survival or time to progression, but reported that the area of thermal damage ranged from 0.95-9.63 cm2, and the median length of hospitalization was 24 hours. Indexing Status Subject indexing assigned by CRD MeSH Epilepsy; Humans; Hyperthermia, Induced; Policy Making; Technology Assessment, Biomedical Language Published English Country of organisation Canada English summary An English language summary is available. Address for correspondence 3rd Floor, TRW Building, University of Calgary, 3280 Hospital Dr NW, Calgary, Alberta, Canada, T2N 4Z6 Email: fclement@ucalgary.ca AccessionNumber 32016000764 Date abstract record published 14/06/2016 |
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