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Use of anti-neuronal antibodies to diagnose paraneoplastic neurological syndromes |
Gonzalez L, Augustovski F, Pichon-Riviere A, García Martí S, Alcaraz A, Bardach A, Ciapponi A, López A, Rey-Ares L |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Gonzalez L, Augustovski F, Pichon-Riviere A, García Martí S, Alcaraz A, Bardach A, Ciapponi A, López A, Rey-Ares L. Use of anti-neuronal antibodies to diagnose paraneoplastic neurological syndromes. Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rapida No. 473. 2016 Authors' conclusions The evidence found supporting the use of anti-neuronal antibodies to diagnose paraneoplastic neurological syndromes is of low quality. The simultaneous use of antibodies shows low sensitivity and high specificity. In subjects with classical clinical manifestations, but without cancer diagnosis, its use could guide the search for underlying neoplasm and confirming their association.
Despite the fact that there is limited evidence, some expert consensuses support anti-Hu, Yo, CV2, Ri, Ma2, and amphiphysin antibody screening in patients with specific neurological manifestations without detectable neoplasm. They suggest their simultaneous investigation, since most syndromes are not specifically related to a particular type of antibody. Different United States private health sponsors authorize their screening in those subjects with neurological manifestations, when diagnostic doubts persist, and for those who meet specific criteria.
Final publication URL www.iecs.org.ar Indexing Status Subject indexing assigned by CRD MeSH Autoantibodies; Humans; Paraneoplastic Syndromes Language Published Spanish Country of organisation Argentina English summary An English language summary is available. Address for correspondence Institute for Clinical Effectiveness and Health Policy, Viamonte 2146 - 3 Piso, C1056ABH Ciudad de Buenos Aires, Argentina Tel: +54 11 49 66 00 82 Fax:+54 11 49 53 40 58 Email: info@iecs.org.ar AccessionNumber 32016001125 Date abstract record published 02/12/2016 |
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