Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Comparative effectiveness of sugammadex versus neostigmine for reversal of neuromuscular blockade following surgery in adult patients
. Lansdale: HAYES, Inc.. Directory Publication. 2016 Authors' objectives Sugammadex (SUG) is indicated for the reversal of neuromuscular blockade (NMB) induced by rocuronium bromide and vecuronium bromide during surgery. SUG selectively binds to neuromuscular blocking agents, thereby preventing further attachment of the NMB agents to acetylcholine receptors and facilitating the return of muscle function. SUG may provide complete reversal of NMB regardless of the level of blockade.
Controversy: The comparative effectiveness and safety of SUG relative to NEO has not yet been established, and questions remain regarding whether use of SUG results in improvements in quality-of-life (QOL) and functional outcomes. In addition, the potential benefits of SUG may not be sufficient to offset its high cost.
Relevant Questions: How does SUG compare with NEO with regard to reversal of NMB following surgery?
How does SUG compare with NEO with regard to safety for patients following surgery? How does SUG compare with NEO with regard to functional and QOL outcomes? Have definitive patient selection criteria been established for SUG? Indexing Status Subject indexing assigned by CRD MeSH Adult; Humans; Neostigmine; Neuromuscular Blockade; Neuromuscular Nondepolarizing Agents; gamma-Cyclodextrins Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: hayesinfo@hayesinc.com AccessionNumber 32017000054 Date abstract record published 05/01/2017 |