Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Comparative effectiveness review of high-frequency left repetitive transcranial magnetic stimulation versus other neurostimulation approaches to treatment-resistant depression
. Lansdale: HAYES, Inc.. Directory Publication. 2016 Authors' objectives Repetitive high-frequency left transcranial magnetic stimulation (HFL-rTMS) is a noninvasive technique that may serve as an alternative intervention for treatment-resistant depression (TRD). Brief repetitive pulses of magnetic energy are applied to the scalp via a large electromagnetic coil, thereby modulating electrical current in the underlying cortical tissue. The goal of HFL-rTMS is to influence activity in areas of the brain involved in mood regulation, in order to shorten the duration or reduce the severity of depressive episodes. HFL-rTMS may be used to augment current pharmacotherapy or as a primary treatment strategy for medication-free patients.
Controversy: The comparative effectiveness and safety of HFL-rTMS relative to electroconvulsive therapy (ECT),
ECT combined with HFL-rTMS (ECT+HFL-rTMS), and bilateral repetitive transcranial magnetic stimulation (rTMS) in patients who have not responded to pharmacotherapy are unknown.
Relevant Questions: How does HFL-rTMS compare with ECT and bilateral rTMS with regard to improvement of depression symptoms for patients with TRD? How does HFL-rTMS compare with ECT and bilateral rTMS with regard to rates of response and remission for patients with TRD? How does HFL-rTMS compare with ECT and bilateral rTMS with regard to safety for patients with TRD? Have definitive patient selection criteria been established for HFL-rTMS, ECT, and bilateral rTMS? Indexing Status Subject indexing assigned by CRD MeSH Depression; Depressive Disorder, Treatment-Resistant; Electroconvulsive Therapy; Humans; Transcranial Magnetic Stimulation Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: hayesinfo@hayesinc.com AccessionNumber 32017000055 Date abstract record published 05/01/2017 |