Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. Antibiotic-impregnated bone cement for total hip arthroplasty and other orthopedic indications. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Antibiotic bone cement (ABC) is a type of curable polymethacrylate preparation created by adding various antibiotic medications to plain, nonmedicated bone cement. This material is used to fix the components of joint replacement devices or fractured bones. It may also be used as a delivery system for antibiotics to prevent or treat many types of deep musculoskeletal infections. Most commonly, ABC is used to treat infected total joint prostheses as part of revision arthroplasty, but its use as antibiotic prophylaxis in primary joint arthroplasty is increasing.
Rationale: ABC at the arthroplasty site or site of bone infection may be useful in maintaining a locally high level of antibiotic drug concentration. These high levels may not be achieved without the potential systemic toxicity associated with intravenous administration. Controversy: Controversial issues related to the clinical use of ABCs include the safety and effectiveness of ABCs compared with other fixation methods, optimal antibiotic choice and dose, optimal cement preparation technique, costeffectiveness
of ABCs, the appropriate use of ABC in a prophylactic setting, antimicrobial resistance, and patient selection (i.e., which patients might benefit the most from the treatment).
Relevant Questions:
Is ABC effective in preventing infection in primary hip or shoulder arthroplasty?
Is ABC effective in treating or preventing recurrence of infection in revision hip arthroplasty?
Is ABC effective for preventing or treating musculoskeletal infections related to other orthopedic indications (e.g., trauma or bone disease)?
How does ABC compare with alternative interventions for prevention or treatment of infection? What harms and complications are associated with ABC?
Are the rates of these harms different from those experienced with alternative treatments?
Have definitive patient selection criteria been established for the use of ABC? Indexing Status Subject indexing assigned by CRD MeSH Anti-Bacterial Agents; Arthroplasty, Replacement, Hip; Bone Cements; Humans; Orthopedics; Prosthesis-Related Infections Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: hayesinfo@hayesinc.com AccessionNumber 32017000366 Date abstract record published 19/09/2017 |