Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. Positron emission tomography-computed tomography (PET-CT) for detection of primary site in neuroendocrine tumors of unknown origin. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Rationale:
Combined positron emission tomography-computed tomography (PET-CT) has emerged as a tool for detecting and delineating lesions, staging and restaging disease, and predicting and monitoring response to treatment. The rationale for this imaging strategy is that accuracy may be improved by combining 2 types of data. Technology Description:
PET-CT is an imaging technique that merges physiologic data from positron emission tomography (PET) and morphologic data from computed tomography (CT). The goal of PET-CT as a diagnostic tool for patients with
neuroendocrine tumors (NETs) with an unknown primary site is to provide optimal imaging capability by minimizing misalignment between PET and CT images in order to identify and localize primary tumors. Controversy:
PET-CT offers an alternative to other conventional diagnostic modalities for the identification and localization of unknown primary tumors in patients with metastatic NETs. However, a definitive reference standard other than histopathology for detection of unknown primary tumors is lacking, which makes evaluation of PET-CT for this indication challenging.
Key Questions
Can PET-CT accurately localize the primary tumor in patients with NETs of unknown origin? Does use of PET-CT in patients with NETs with primary tumors of unknown origin change patient management or improve outcomes? Is PET-CT in patients with NETs of unknown origin safe? Have definitive patient selection criteria for the use of PET-CT for identifying primary tumor in patients with NETs of unknown origin been established? Indexing Status Subject indexing assigned by CRD MeSH Humans; Neuroendocrine Tumors; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: hayesinfo@hayesinc.com AccessionNumber 32018000032 Date abstract record published 30/01/2018 |